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All these roles are conserved in higher species, and new ones have emerged in parallel with the increase in functional complexity associated with the development of new organs (brain, liver, kidney, etc) or evolving functions (complex behaviors, tissue healing, etc)

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However, several studies have shown that GLS2 is highly expressed in triple-negative basal-like breast cancer (TNBC) and metastatic lung cancer and that it confers radioresistance in advanced human cervical cancer cells, suggesting that GLS2 may reduce reactive oxygen species (ROS) levels by increasing the level of cellular reduced glutathione (GSH), NADH, or NADPH 14,15,16

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